| CAS NO: | 70713-45-0 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 20mg | 电议 |
| Cas No. | 70713-45-0 |
| Canonical SMILES | C=CCN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1 |
| 分子式 | C20H24N2 |
| 分子量 | 292.42 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties. Aligeron shows a broad spectrum of antagonistic action against different spasmogens in different isolated organs. The experiments on isolated perfused rabbit artery shows the antagonistic action of aligeron against the vasoconstrictor effects of noradrenaline and adrenaline[1]. The effect of aligeron in vitro lacks selectivity and is probably due to interference with the action of Ca2+[3]. In hypoventilation hypoxia, aligeron (5 mg/kg i.v.) and cinnarizine increase cortical resistance to hypoxia and accelerated the recovery of cortical bioelectrical activity. In KCl- and AMP-induced depressions aligeron shows a protective effect manifested in a decrease of the degree and duration of the depression[2]. [1]. Miyares K, et al. Antagonistic activity of aligeron and papaverine against different smooth muscle stimuli. Methods Find Exp Clin Pharmacol. 1985 Sep;7(9):473-6. [2]. Dimov S, et al. Effect of aligeron and cinnarizine in models of general and local depression of the cortical bioelectrical activity in cats. Methods Find Exp Clin Pharmacol. 1983;5(2):89-95. [3]. Nikolov R, et al. Study on the prostaglandin antagonistic activity of aligeron and piracetam. Methods Find Exp Clin Pharmacol. 1982 Aug-Sep;4(6):387-95. |
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