| CAS NO: | 1404-93-9 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 250mg | 电议 |
| 1g | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 1485.72 |
| Cas No. | 1404-93-9 |
| Formula | C66H76Cl3N9O24 |
| Solubility | ≥55.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; ≥22.15 mg/mL in H2O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Animal experiment:[1] | |
Animal models | C57BL/6 mice challenged withClostridium difficile(C. difficile) strain VPI 10463 |
Dosage form | 20 mg/kg Once daily by oral gavage for 5 days |
Applications | Vancomycin treatment of infected mice was associated with improved clinical, diarrhea, and histopathology scores and survival during treatment. However, after discontinuation of the drug, clinical scores and histopathology were worse in treated mice than in untreated infected controls. Decreasing the duration of vancomycin treatment from 5 days to 1 day decreased recurrence and deaths inC. difficileinfection. |
Note | The technical data provided above is for reference only. |
References: 1. Warren CA, van Opstal EJ, Riggins MS, et al. Vancomycin treatment's association with delayed intestinal tissue injury, clostridial overgrowth, and recurrence of Clostridium difficile infection in mice. Antimicrobial Agents and Chemotherapy, 2013, 57(2): 689-696. | |
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