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Timolol Maleate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Timolol Maleate图片
CAS NO:26921-17-5
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议
250mg电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at -20°C
M.Wt432.49
Cas No.26921-17-5
FormulaC17H28N4O7S
Solubility≥21.62 mg/mL in DMSO; ≥10.53 mg/mL in EtOH; ≥11.83 mg/mL in H2O
Chemical Name(Z)-but-2-enedioic acid;(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
Canonical SMILESCC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O.C(=CC(=O)O)C(=O)O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

(S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively).

试验操作

Animal experiment:[1]

Animal models

Adult male Wistar rats, 9 weeks of age, 250 ~ 300 g

Dosage form

0.5% timolol maleate

Topically applied daily, started 1 week after the laser photocoagulation and lasted for 3 weeks

Applications

In rats subjected to intracameral injection of India ink and subsequent laser trabecular photocoagulation, timolol maleate induced a significant reduction in intraocular pressure (IOP) and counteracted the reduction in retinal ganglion cell (RGC) number that occurred in vehicle treated glaucomatous eyes. Thus, timolol maleate was able to reduce IOP and protected RGCs in a rat model of experimental glaucoma.

Note

The technical data provided above is for reference only.

References:

1. Seki M, Tanaka T, Matsuda H, et al. Topically administered timolol and dorzolamide reduce intraocular pressure and protect retinal ganglion cells in a rat experimental glaucoma model. British Journal of Ophthalmology, 2005, 89(4): 504-507.