您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Sodium ascorbate
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Sodium ascorbate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Sodium ascorbate图片
CAS NO:134-03-2
包装与价格：
包装价格(元)
10mM (in 1mL H2O)电议
1g电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at -20°C
M.Wt198.11
Cas No.134-03-2
FormulaC6H7NaO6
Solubilityinsoluble in EtOH; insoluble in DMSO; ≥9.1 mg/mL in H2O
Chemical Namesodium (R)-2-((S)-1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate
Canonical SMILESO=C1C(O)=C([O-])[C@@H]([C@@H](O)CO)O1.[Na+]
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.

试验操作

Cell experiment:[1]

Cell lines

Human glioblastoma multiforme (GBM), rat prostate cancer (PC) and normal mouse 3T3 cells

Reaction Conditions

1 ~ 14 mM sodium ascorbate

Applications

Sodium ascorbate considerably decreased the proliferation and motility of GBM and PC cells. This effect was accompanied by intracellular ROS over-production and necrotic death of tumor cells, apparently resulting from their "autoschizis".

Animal experiment:[1]

Animal models

Male Wistar rats, 200 ~ 230 g

Dosage form

1 or 2 mg/kg

Injected intravenously at 3rd and 7th day after U87 cell implantation

Applications

In U87 tumor-bearing rats, intravenous administration of sodium ascorbate inhibited tumor invasionin vivoand seemed to reduce the size of neoplasia. Concomitantly, blood analyses did not show any signs of hemolysis or biochemical disorders after sodium ascorbate administration. High doses of sodium ascorbate were demonstrated to interfere with the expansion of GBM cellsin vitroandin vivo.

Note

The technical data provided above is for reference only.

References:

1. Ryszawy D, Pudelek M, Catapano J, et al. High doses of sodium ascorbate interfere with the expansion of glioblastoma multiforme cells in vitro and in vivo. Life Sciences, 2019, 232: 116657.