| CAS NO: | 103-90-2 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 151.16 |
| Cas No. | 103-90-2 |
| Formula | C8H9NO2 |
| Solubility | insoluble in H2O; ≥29.4 mg/mL in EtOH; ≥7.56 mg/mL in DMSO |
| Chemical Name | (Z)-N-(4-hydroxyphenyl)acetimidic acid |
| Canonical SMILES | C/C(O)=N/C1=CC=C(O)C=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with IC50 of 25.8 μM, It is a widely used antipyretic analgesic[1].
Paracetamol (50 mM) significantly reduces cell viability. But co-treatment with acetaminophen and HV110 can significantly increase cell viability[2].
Paracetamol (250 mg / kg) reduces glutathione levels and glutathione peroxidase activity in mice, and induces mast cell death and hypertrophy in primary mouse liver cells The inhibitor ferrostatin-1 can block this effect. Paracetamol has analgesic and antipyretic effects in animal models.
References:
[1]. Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man, 2008, 22(2): 383-90.
[2]. Dini M, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol, 2017, 8: 594.
[3]. Lorincz T, Jemnitz K, Kardon T, et al. Ferroptosis is Involved in Acetaminophen Induced Cell Death. Pathology & Oncology Research, 2015, 21(4): 1115-1121.
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