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Moxidectin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Moxidectin图片
CAS NO:113507-06-5
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at -20°C
M.Wt639.82
Cas No.113507-06-5
FormulaC37H53NO8
Solubility≥128 mg/mL in EtOH; ≥129.4 mg/mL in DMSO; ≥3.27 mg/mL in H2O with gentle warming and ultrasonic
Canonical SMILESCC(/C([H])=C([C@](O1)([H])[C@@](/C(C[C@@]21C[C@](O3)([H])C[C@@](O2)([H])C/C([H])=C(C[C@@](/C([H])=C([H])/C([H])=C([C@@]45O)\CO[C@]5([H])[C@@](O)([H])C(C)=C[C@@]4([H])C3=O)([H])C)\C)=N\OC)([H])C)\C)C
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Moxidectin is a macrocyclic lactone anthelmintic drug used to control or prevent parasitic worms. Its principal use is veterinary, in animals ranging from cats and dogs to horses and cattle. Moxidectin-susceptible parasites includeStrongylus vulgarisin horses andOstertagia ostertagiin cattle. In 2018, moxidectin was approved by FDA for treating onchocerciasis (river-blindness) caused by the parasitic wormOnchocerca volvulus.

References:

1. Rolfe PF, Dawson KL, Holm-Martin M. Efficacy of moxidectin and other anthelmintics against small strongyles in horses. Australian Veterinary Journal, 1998, 76(5): 332-334.

2. Hubert J, Kerboeuf D, Cardinaud B, et al. Persistent efficacy of topical moxidectin against Dictyocaulus viviparus and Ostertagia ostertagi. Veterinary Parasitology, 1997, 68(1-2): 187-190.

3. Awadzi K, Opoku NO, Attah SK, et al. A randomized, single-ascending-dose, ivermectin-controlled, double-blind study of moxidectin in Onchocerca volvulus infection. PLOS Neglected Tropical Diseases, 2014, 8(6): e2953.

试验操作

Animal experiment:[1]

Animal models

Shetland horses aged 1 to 32 years

Dosage form

0.4 mg/kg

Anthelmintic drug in pastes applied to the base of the tongue

Applications

Moxidectin was highly effective in reducing faecal egg counts after treatment for at least 12 weeks and up to 16 weeks in most horses.

Note

The technical data provided above is for reference only.

References:

1. Rolfe PF, Dawson KL, Holm-Martin M. Efficacy of moxidectin and other anthelmintics against small strongyles in horses. Australian Veterinary Journal, 1998, 76(5): 332-334.

2. Hubert J, Kerboeuf D, Cardinaud B, et al. Persistent efficacy of topical moxidectin against Dictyocaulus viviparus and Ostertagia ostertagi. Veterinary Parasitology, 1997, 68(1-2): 187-190.

3. Awadzi K, Opoku NO, Attah SK, et al. A randomized, single-ascending-dose, ivermectin-controlled, double-blind study of moxidectin in Onchocerca volvulus infection. PLOS Neglected Tropical Diseases, 2014, 8(6): e2953.