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(S)-(-)-Propranolol hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(S)-(-)-Propranolol hydrochloride图片
CAS NO:4199-10-4
包装与价格：
包装价格(元)
10mM (in 1mL H2O)电议
100mg电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at RT
M.Wt295.81
Cas No.4199-10-4
FormulaC16H21NO2·HCl
Solubility≥15.65 mg/mL in H2O; ≥2.9 mg/mL in EtOH with gentle warming and ultrasonic; ≥57.5 mg/mL in DMSO
Chemical Name(S)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride
Canonical SMILESO[C@H](COC1=CC=CC2=CC=CC=C12)CNC(C)C.Cl
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

(S)-(-)-Propranolol hydrochloride is a more active enantiomer of propranolol, acting as a β-adrenoceptor antagonist with logKdvalues being -8.16, -9.08 and -6.93 for human β1-, β2- and β3-adrenoceptors stably expressed in Chinese hamster ovary cells, respectively. β-Adrenoceptor antagonists are one of the most commonly used classes of drugs in cardiovascular medicine (hypertension, ischemic heart disease and heart failure) as well as in the management of anxiety, migraine and glaucoma. In addition, (S)-(-)-propranolol hydrochloride is also a non-specific serotonin receptor antagonist, capable of inhibiting the behavioral responses to increased brain 5-hydroxytryptamine (5-HT).

References:

1. Baker JG. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. British Journal of Pharmacology, 2005, 144(3): 317-322.

2. Costain DW, Green AR. beta-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamine. British Journal of Pharmacology, 1978, 64(2): 193-200.

3. Barrett AM, Cullum VA. The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. British Journal of Pharmacology, 1968, 34(1): 43-55.

试验操作

Animal experiment:[3]

Animal models

Cats anaesthetized with halothane

Dosage form

From 0.05 mg/kg to the dose at which the arrhythmia to adrenaline was abolished

Given intravenously

Applications

Both (S)-(-)-propranolol and (S)-(+)-propranolol were capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane, but the mean dose of (S)- (-)-propranolol was 0.09 ± 0.02 mg/kg whereas that of (S)-(+)-propranolol was 4.2 ± 1.2 mg/kg.

Note

The technical data provided above is for reference only.

References:

1. Baker JG. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. British Journal of Pharmacology, 2005, 144(3): 317-322.

2. Costain DW, Green AR. beta-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamine. British Journal of Pharmacology, 1978, 64(2): 193-200.

3. Barrett AM, Cullum VA. The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. British Journal of Pharmacology, 1968, 34(1): 43-55.