| CAS NO: | 3483-12-3 |
| 包装: | 25g |
| 市场价: | 1290元 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 154.25 |
| Cas No. | 3483-12-3 |
| Formula | C4H10O2S2 |
| Solubility | ≥15.4 mg/mL in H2O; ≥34 mg/mL in DMSO; ≥37.4 mg/mL in EtOH |
| Chemical Name | (2S,3S)-1,4-dimercaptobutane-2,3-diol |
| Canonical SMILES | SC[C@H]([C@@H](CS)O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
DL-Dithiothreitol is capable of maintaining monothiols completely in the reduced state and of reducing disulfides quantitatively. Thiol groups such as those of coenzyme A are readily oxidized in air to disulfides. To maintain these groups in the reduced state, another thiol is often added so that interchange takes place. Since DL-dithiothreitol is a highly alcohol- and water-soluble solid with little odor and little tendency to be oxidized directly by air, it proves much superior to the thiols currently used as protective reagents for sulfhydryl groups. DL-Dithiothreitol is commonly used in a variety of experiments that involve peptides or proteins, protecting sulfhydryl groups from oxidation and reducing disulfide bonds between cysteines. DL-Dithiothreitol also acts as an "antidote" enabling the activity of detoxification systems, and is used in the treatment approach of diseases like cystinosis or medical conditions resulting from ion or metal toxicity.
References:
1. Cleland WW. Dithiothreitol, a new protective reagent for SH groups. Biochemistry, 1964, 3: 480-482.
2. Lopes de Almeida JP, Saldanha C. Dithiothreitol revisited in red cells: a new head for an old hat. Clinical Hemorheology and Microcirculation, 2010, 46(1): 51-56.
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