(5Z)-7-Oxozeaenol

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(5Z)-7-Oxozeaenol

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

253863-19-3

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品介绍

化学性质

Physical Appearance	White solid
Storage	Desiccate at -20°C
M.Wt	362.37
Cas No.	253863-19-3
Formula	C₁₉H₂₂O₇
Solubility	<9.06mg/ml in DMSO;insoluble in ethanol
Chemical Name	(3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione
Canonical SMILES	O[C@@H](C/C=C/C(C=C1OC)=C(C(O)=C1)C(O[C@@H](C)C/C=C\C2=O)=O)[C@@H]2O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

(5Z)-7-Oxozeaenol is a natural resorcylic lactone derived from fungi that selectively inhibits purified TAK-1 (IC50 = 8.1 nM) without significantly affecting the kinase activities of other MAPKKK family members.

In cells, (5Z)-7-Oxozeaenol is reported to irreversibly block IL-1-induced activation of TAK-1, NF-κB, and JNK/p38 with IC50 values of 65-83 nM.

(5Z)-7-Oxozeaenol has also been shown to inhibit IL-1-induced COX-2 production in cells and to relieve ear swelling induced by picryl chloride in a mouse model of COX-2-mediated inflammation.

Reference:

[1]. Ninomiya-Tsuji J, Kajino T, Ono K, et al. A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J. Biol. Chem, 2003, 278(20): 18485-18490.

试验操作

Cell experiment:[1]
Cell lines	Mouse embryonic fibroblast cells
Reaction Conditions	500 nM (5Z)-7-oxozeaenol for 17.5 h incubation
Applications	In cell culture, (5Z)-7-oxozeaenol blocked interleukin-1-induced activation of TAK1, JNK/p38 MAPK, IκB kinases, and NF-κB, resulting in inhibition of cyclooxgenase-2 production.
Animal experiment:[1]
Animal models	Mice repeatedly sensitized by picryl chloride (PC) and subsequently challenged with PC
Dosage form	10 μl of (5Z)-7-oxozeaenol (1 mg/ml) Painted on each ear 2 h before and 4 h after the second PC challenge (total of twice) or every hour three times before and 4 h after the second PC challenge (total of four times)
Applications	When (5Z)-7-oxozeaenol was administrated to the PC-challenged ear, ear swelling was reduced by up to 50% of that of the control ear treated with vehicle. Thus, (5Z)-7-oxozeaenol was able to prevent inflammation by inhibiting the catalytic activity of TAK1 MAPKKK.
Note	The technical data provided above is for reference only.
	References: 1. Ninomiya-Tsuji J, Kajino T, Ono K, et al. A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. Journal of Biological Chemistry, 2003, 278(20): 18485-18490.