| CAS NO: | 2188-68-3 |
| 包装: | 20mg |
| 市场价: | 357元 |
| Cas No. | 2188-68-3 |
| 别名 | 石蒜碱 |
| 化学名 | (1S,2S,3a1S,12bS)-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride |
| Canonical SMILES | Cl[H].[H][C@@]1([C@@](C2=C([H])C3=C4OC([H])([H])O3)([H])[C@]5([H])O[H])N(C([H])([H])C2=C4[H])C([H])([H])C([H])([H])C1=C([H])[C@]5([H])O[H] |
| 分子式 | C16H18ClNO4 |
| 分子量 | 323.77 |
| 溶解度 | ≥ 32.4mg/mL in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radia and is also a melanoma vasculogenic inhibitor and has anti-tumor activity[1]. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM)[2]. Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected[1].Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion[1]. Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry[1]. References: |
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