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Pinocembrin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pinocembrin图片
CAS NO:480-39-7
包装:20mg
市场价:2436元

产品介绍
Pinocembrin ((+)-Pinocoembrin) 是一种在蜂胶中发现的类黄酮,作为组氨酸脱羧酶的竞争性抑制剂,是一种有效的抗过敏剂,具有抗氧化、抗菌和抗炎的特性。
Cas No.480-39-7
别名乔松素; (+)-Pinocoembrin; Dihydrochrysin; Galangin flavanone
化学名(2S)-5,7-dihydroxy-2-phenyl-2,3-dihydrochromen-4-one
Canonical SMILESC1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=CC=C3
分子式C15H12O4
分子量256.25
溶解度DMSO : 125 mg/mL (487.80 mM)
储存条件Store at 2-8°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties[1].

Pinocembrin (5, 10, 25, 50, 100 or 200 μM, 24 hours) significantly reduces cell viability of RBL-2H3 cells[1].Pinocembrin (25 or 50 μM) suppresses iNOS, PGE-2 and COX-2 levels, increases p38-Mapk and IкB-α, and inhibits phosphorylation of IкB-α[1].

References:
[1]. Hanieh H, et al. Pinocembrin, a novel histidine decarboxylase inhibitor with anti-allergic potential in in vitro. Eur J Pharmacol. 2017 Nov 5;814:178-186.