| CAS NO: | 117946-91-5 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 292.38 |
| Cas No. | 117946-91-5 |
| Formula | C19H20N2O |
| Solubility | ≥68.8 mg/mL in DMSO; ≥88.2 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | N-(2-(2-benzyl-1H-indol-3-yl)ethyl)acetamide |
| Canonical SMILES | O=C(C)NCCC1=C(CC2=CC=CC=C2)NC3=CC=CC=C13 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Luzindole is a melatonin receptor antagonist that preferentially targets MT2 over MT1. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity[1-3].
Luzindole (30 mg/kg i.p.) reduces the immobile time in a dose-dependent manner, reducing midnight by 60% and noon by 39%. Luzindole shows the greatest effect at 60 minutes. In albinism ND/4 mice or C57BL/6J mice that do not produce melatonin, Luzindole (30 mg/kg i.p.) does not change the immobile time at noon or midnight[3].
References:
[1]. Dubocovich M L, et al. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn Schmiedebergs Arch Pharmacol, 1997, 355(3): 365-75.
[2]. Constantinescu C S, et al. Luzindole, a melatonin receptor antagonist, suppresses experimental autoimmune encephalomyelitis. Pathobiology, 1997, 65(4): 190-4.
[3]. Dubocovich M L Antidepressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in the mouse behavioral despair test. Eur J Pharmacol, 1990, 182(2): 313-25.
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