| CAS NO: | 18172-33-3 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 336.39 |
| Cas No. | 18172-33-3 |
| Formula | C20H20N2O3 |
| Solubility | Soluble in DMSO |
| Chemical Name | (6aS,11aR,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-6a,7,11a,11b-tetrahydro-2H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9(6H)-one |
| Canonical SMILES | OC1=C(C(C)=O)C(N2C(C)(C)[C@@H](CC3=C4C5=CNC4=CC=C3)[C@H]5[C@@H]21)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Cyclopiazonic acid is a neurotoxic secondary metabolite produced byA. flavus and is a nanomolar inhibitor of endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA). Cyclobenzoic acid does not inhibit many other types of membrane-bound ATPase, it can effectively inhibit SERCA in intact tissues, smooth muscle and endothelium, and isolated cells[1,2]. It is an effective inducer of plant cell death[3].
References:
[1]. Mumtaz S, Burdyga G, Borisova L, et al. The mechanism of agonist induced Ca2+ signalling in intact endothelial cells studied confocally in in situ arteries. Cell Calcium, 2011, 49(1): 66-77.
[2]. Berra-Romani R, Raqeeb A, Torres-Jácome J, et al. The mechanism of injury-induced intracellular calcium concentration oscillations in the endothelium of excised rat aorta. Journal of Vascular Research, 2012, 49(1): 65-76.
[3]. Chalivendra S C, et al. Cyclopiazonic Acid Is a Pathogenicity Factor for Aspergillus flavus and a Promising Target for Screening Germplasm for Ear Rot Resistance. Mol Plant Microbe Interact, 2017, 30(5): 361-373.
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