| CAS NO: | 149007-54-5 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 468.47 |
| Cas No. | 149007-54-5 |
| Formula | C24H33N3O2·2HCl |
| Solubility | <46.85mg/ml in DMSO;insoluble in H2O;insoluble in H2O |
| Chemical Name | (S,Z)-N-(tert-butyl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)-2-phenylpropanimidic acid dihydrochloride |
| Canonical SMILES | CC(C)(/N=C(O)/[C@](C1=CC=CC=C1)([H])CN2CCN(C3=CC=CC=C3OC)CC2)C.Cl.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
(S)-WAY 100135 dihydrochloride是一种强效的和选择性的5-HT1A受体拮抗剂,IC50值为15 nM.
5-HT1A受体是一种内源性神经递质血清素(5-HT)的G蛋白偶联受体并介导抑制性神经传递.
(S)-WAY 100135 dihydrochloride是一种强效的和选择性的somatodendritic和突触后5-HT1A受体拮抗剂. (+/-)-WAY100135抑制大鼠海马中的5-HT1A受体,IC50值为34 nM [1].
在小鼠高架十字迷宫试验中,(S)-WAY 100135 (10 mg/kg)表现出抗焦虑样作用[2].在自由采食大鼠中,WAY-100135 (3 mg/kg)显著抑制摄食过度和8-OH-DPAT (0.1 mg/kg)诱导的喂食发生增加,这由somatodendritic 5-HT1A自身受体介导[3].在大鼠中,(S)-WAY 100135 (0.2\1和5 ug/ul)剂量依赖性地抑制海马莨菪(3.75 ug/ul)诱导的选择准确性损伤.然而,(S)-WAY 100135不影响空间学习的习得[4].在大鼠中,WAY-100135 (10.0 mg/kg)抑制丁螺环酮,一种5-HT1A受体部分激动剂诱导的5-羟色胺释放的减少[5].
参考文献：
[1]. Fletcher A, Bill DJ, Bill SJ, et al. WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. Eur J Pharmacol, 1993, 237(2-3): 283-291.
[2]. Rodgers RJ, Cole JC. Anxiolytic-like effect of (S)-WAY 100135, a 5-HT1A receptor antagonist, in the murine elevated plus-maze test. Eur J Pharmacol, 1994, 261(3): 321-325.
[3]. Hartley JE, Fletcher A. The effects of WAY-100135 and 8-hydroxy-2-(di-n-propylamino)tetralin on feeding in the rat. Eur J Pharmacol, 1994, 252(3): 329-332.
[4]. Carli M, Luschi R, Samanin R. (S)-WAY 100135, a 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine. Eur J Pharmacol, 1995, 283(1-3): 133-139.
[5]. Routledge C, Gurling J, Ashworth-Preece MA, et al. Differential effects of WAY-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and NAN-190. Eur J Pharmacol, 1995, 276(3): 281-284.
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