| CAS NO: | 82749-70-0 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 427.37 |
| Cas No. | 82749-70-0 |
| Formula | C22H28Cl2O4 |
| Solubility | insoluble in H2O; ≥49.8 mg/mL in EtOH; ≥50.8 mg/mL in DMSO |
| Chemical Name | (R)-4-((2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)butanoic acid |
| Canonical SMILES | ClC1=C2C([C@@](CC2=CC(OCCCC(O)=O)=C1Cl)(CCCC)C3CCCC3)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
DCPIB is a volume-regulated anion channel (VRAC) blocker (IC50 = 2 μM in rat pancreatic β-cells)[1], which is also a blocker of swelling-induced chloride current (ICl, swell) in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells)[2].
In intact β-cells, DCPIB inhibits glucose-stimulated insulin secretion through VSAC inhibition and indirect KATP channel activation. DCPIB reverses the shortened duration of action potential induced by cell swelling in atrial myocytes and inhibits astrocyte swelling in vitro. DCPIB (10 μM) also activates TREK1 and TRAAK K+ channels and inhibits TRESK, TASK1 and TASK3 K+ channels in vitro[3].
References:
[1]. Best L, Yates A P, Decher N, et al. Inhibition of glucose-induced electrical activity in rat pancreatic β-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents. european journal of pharmacology, 2004, 489(1-2): 13-19.
[2].Decher N, et al. DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br J Pharmacol, 2001, 134(7): 1467-79.
[3]. Lv J, et al. DCPIB, an Inhibitor of Volume-Regulated Anion Channels, Distinctly Modulates K2P Channels. ACS Chem Neurosci, 2019.
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