BRD4770

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BRD4770

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1374601-40-7

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议
100mg	电议

产品介绍

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	413.47
Cas No.	1374601-40-7
Formula	C₂₅H₂₃N₃O₃
Solubility	insoluble in DMSO; insoluble in H2O; insoluble in EtOH
Chemical Name	methyl 2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylate
Canonical SMILES	COC(=O)C1=CC2=C(C=C1)N(C(=N2)NC(=O)C3=CC=CC=C3)CCCC4=CC=CC=C4
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

BRD4770 is a histone methyltransferase G9a inhibitor with an IC50 of 6.3 μM and induces cell death[1].

In pancreatic cancer cell line PANC-1, BRD4770 reduces intracellular di- and trimethylated H3K9 levels through inhibition of G9a, induces senescence, and inhibits adherent-dependent and independent proliferation[1].

Reference：

[1]. Yuan Y, et al. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem Biol, 2012, 7(7): 1152-7.