您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Angiotensin(1-7)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Angiotensin(1-7)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Angiotensin(1-7)图片
CAS NO:51833-78-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍

化学性质

Physical AppearanceA solid
StorageDesiccate at -20°C
M.Wt899
Cas No.51833-78-4
FormulaC41H62N12O11
SynonymsAsp-Arg-Val-Tyr-Ile-His-Pro
Solubilityinsoluble in EtOH; ≥48.5 mg/mL in H2O; ≥89.9 mg/mL in DMSO
Chemical NameAngiotensin (1-7)
Canonical SMILESCCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Ang(1-7)的氨基酸序列为H - Asp - Arg - Val - Tyr - Ile - His - Pro – OH,是血管紧张素I或血管紧张素Ⅱ在内肽酶或羧基肽酶作用下产生的内源性肽片段[1]。

最初发现的Ang(1-7)主要在心血管和肾脏中发挥功能,Ang(1-7)与血管紧张素Ⅱ类似,在不同器官和组织广泛分布,发挥作用。这些作用是由Mas介导的,可以反向调节血管紧张素Ⅱ造成的大部分有害影响。Ang(1-7)/Mas的相互作用调节不同的信号通路,如PI3K(磷酸肌醇3-激酶)/AKT和ERK(胞外信号调节激酶)途径,下游效应因子如NO、FOXO1和COX-2(环氧化酶-2)参与其中。通过这些机制,Ang(1-7)能够改善一些病理状况,包括器官的纤维化和炎症,如肺、肝和肾脏[2]。

此外,这种七肽对代谢具有积极的效果,增加葡萄糖摄取和脂肪分解,同时降低胰岛素抗性和血脂异常。除了影响学习和记忆外,在缺血性中风中,Angiotensin (1-7)能够提高脑保护。Ang(1-7)可以作用于生殖系统,具有增强排卵以及精子和类固醇合成的作用。Ang(1-7) 能够抑制细胞增殖和血管生成,被认为是一种潜在的抗癌治疗手段[2]。

 A1041_1

Fig. 1: Formula of Angiotensin (1-7) 

A1041_2 

 

Fig. 2: Cascade of the processing of angiotensin peptides and their interaction with AT1 and AT1-7 receptor systems.

参考文献:

1. Santos et al (2000)Angiotensin-(1-7): an update. Regul.Pept. 91 45.

2. Danielle G. P., Thiago V., Robson A. S. Angiotensin-(1-7): beyond the cardio-renal actions. Clinical Science (2013) 124, (443–456)

试验操作

Cell experiment:[1]

Cell lines

Rat kidney NRK-52E cells

Reaction Conditions

100 nM angiotensin (1-7)

Applications

Angiotensin (1-7) abrogated the methylglyoxal albumin-stimulated myofibroblast phenotype by inhibiting the chronic stimulation of the TGF-β-ERK pathway in NRK-52E cells. Moreover, the inhibitory effects of angiotensin (1-7) on myofibroblast transition could be reversed by the angiotensin (1-7) receptor antagonist A779 (10 μM).

Animal experiment:[2]

Animal models

Male and female BALB/c mice (1:1 ratio, 6 ~ 10 weeks old, mean weight 20 g)

Dosage form

0.01, 0.06, 0.1, 0.3 and 1 mg/kg

Once daily by intraperitoneal route

Applications

Daily angiotensin (1-7) treatment (0.01 ~ 0.06 mg/kg) resulted in significant amelioration of dextran sulfate sodium-induced colitis, whereas daily administration of A779 significantly worsened features of colitis. Colitis-associated phosphorylation of p38, ERK1/2 and Akt was also reduced by angiotensin (1-7) treatment.

Note

The technical data provided above is for reference only.

References:

1. Alzayadneh EM, Chappell MC. Angiotensin-(1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2. Cellular Signalling, 2014, 26(12): 3027-3035.

2. Khajah MA, Fateel MM, Ananthalakshmi KV, et al. Anti-inflammatory action of angiotensin 1-7 in experimental colitis. PLoS One, 2016, 11(3): e0150861.