Angiotensin(1-7)

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Angiotensin(1-7)

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CAS NO:

51833-78-4

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Desiccate at -20°C
M.Wt	899
Cas No.	51833-78-4
Formula	C₄₁H₆₂N₁₂O₁₁
Synonyms	Asp-Arg-Val-Tyr-Ile-His-Pro
Solubility	insoluble in EtOH; ≥48.5 mg/mL in H2O; ≥89.9 mg/mL in DMSO
Chemical Name	Angiotensin (1-7)
Canonical SMILES	CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Ang(1-7)的氨基酸序列为H - Asp - Arg - Val - Tyr - Ile - His - Pro – OH，是血管紧张素I或血管紧张素Ⅱ在内肽酶或羧基肽酶作用下产生的内源性肽片段[1]。

最初发现的Ang(1-7)主要在心血管和肾脏中发挥功能，Ang(1-7)与血管紧张素Ⅱ类似，在不同器官和组织广泛分布，发挥作用。这些作用是由Mas介导的，可以反向调节血管紧张素Ⅱ造成的大部分有害影响。Ang(1-7)/Mas的相互作用调节不同的信号通路，如PI3K（磷酸肌醇3-激酶）/AKT和ERK（胞外信号调节激酶）途径，下游效应因子如NO、FOXO1和COX-2（环氧化酶-2）参与其中。通过这些机制，Ang(1-7)能够改善一些病理状况，包括器官的纤维化和炎症，如肺、肝和肾脏[2]。

此外，这种七肽对代谢具有积极的效果，增加葡萄糖摄取和脂肪分解，同时降低胰岛素抗性和血脂异常。除了影响学习和记忆外，在缺血性中风中，Angiotensin (1-7)能够提高脑保护。Ang(1-7)可以作用于生殖系统，具有增强排卵以及精子和类固醇合成的作用。Ang(1-7) 能够抑制细胞增殖和血管生成，被认为是一种潜在的抗癌治疗手段[2]。

A1041_1

Fig. 1: Formula of Angiotensin (1-7)

A1041_2

Fig. 2: Cascade of the processing of angiotensin peptides and their interaction with AT1 and AT1-7 receptor systems.

参考文献：

1. Santos et al (2000)Angiotensin-(1-7): an update. Regul.Pept. 91 45.

2. Danielle G. P., Thiago V., Robson A. S. Angiotensin-(1-7): beyond the cardio-renal actions. Clinical Science (2013) 124, (443–456)

试验操作

Cell experiment:[1]
Cell lines	Rat kidney NRK-52E cells
Reaction Conditions	100 nM angiotensin (1-7)
Applications	Angiotensin (1-7) abrogated the methylglyoxal albumin-stimulated myofibroblast phenotype by inhibiting the chronic stimulation of the TGF-β-ERK pathway in NRK-52E cells. Moreover, the inhibitory effects of angiotensin (1-7) on myofibroblast transition could be reversed by the angiotensin (1-7) receptor antagonist A779 (10 μM).
Animal experiment:[2]
Animal models	Male and female BALB/c mice (1:1 ratio, 6 ~ 10 weeks old, mean weight 20 g)
Dosage form	0.01, 0.06, 0.1, 0.3 and 1 mg/kg Once daily by intraperitoneal route
Applications	Daily angiotensin (1-7) treatment (0.01 ~ 0.06 mg/kg) resulted in significant amelioration of dextran sulfate sodium-induced colitis, whereas daily administration of A779 significantly worsened features of colitis. Colitis-associated phosphorylation of p38, ERK1/2 and Akt was also reduced by angiotensin (1-7) treatment.
Note	The technical data provided above is for reference only.
	References: 1. Alzayadneh EM, Chappell MC. Angiotensin-(1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2. Cellular Signalling, 2014, 26(12): 3027-3035. 2. Khajah MA, Fateel MM, Ananthalakshmi KV, et al. Anti-inflammatory action of angiotensin 1-7 in experimental colitis. PLoS One, 2016, 11(3): e0150861.