| 包装 | 价格(元) |
| 10ug | 电议 |
| 50ug | 电议 |
| 1mg | 电议 |
| Gene ID: | 21926 | Accession #: | P06804.2 |
| Alternate Names: | TNF alpha; TNF-a; cachectin; tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha. | ||
| Source: | Escherichia Coli. | M.Wt: | 17.4 kDa |
| Appearance: | Lyophilized powder | Storage: | Store at -20°C |
| Formulation: | Steriled and lyophilized from 5 mM Tris, pH 8.0. | ||
| Solubility: | Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4℃ for 1 week or -20℃ for future use. | ||
| Shipping Condition: | Gel pack. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. | ||
Tumor Necrosis Factor-α (TNF-α) is a potent cytokine expressed as a transmembrane protein with 235 aa that is cleaved to the soluble monomer by TNF-α converting enzyme (TACE) and forms stable homotrimers. TNF-α is expressed in many cells and plays an important role in inflammation, viral replication, tumorigenesis, apoptosis, cell proliferation, differentiation, coagulation and lipid metabolism. TNF-α is mainly produced by macrophages when challenged with viruses or bacteria. TNF-α is cytotoxic for many tumor cells lines but induced activation, differentiation or proliferation in normal cells. Tumor necrosis factor receptor TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR are receptors for murine TNF-α.
| Determined by the cytolysis of murine L929 cells in the presence of actinomycin D. | ||||||
| ED50 | < 0.1 ng/ml. | |||||
| Specific activity | > 1*107units/mg. | |||||
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