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IL-6,rat recombinant
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IL-6,rat recombinant图片
包装与价格:
包装价格(元)
10ug电议
50ug电议
1mg电议

产品介绍

描述

Gene ID:24498Accession #:P20607
Alternate Names:IL6, IFN-b2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2, IL-6, Interleukin HP-1, B-cell hybridoma growth factor.
Source:Escherichia Coli.M.Wt:21.7 kDa
Appearance:Lyophilized proteinStorage:Store at -20°C
Formulation:Lyophilized with no additives.
Solubility:Reconstitute in 10 mM HCl to a concentration of 0.1-1.0 μg/μl. This solution can then be diluted into other aqueous buffers and stored at 4℃ for 1 week or -20℃ for future use.
Shipping Condition:Blue ice.Handling:Centrifuge the vial prior to opening.
Usage:For Research Use Only! Not to be used in humans.

资料参考

Interleukin-6 (IL-6) is a pleiotropic cytokine produced by activated T cells, monocytes, fibroblasts, endothelial cells, keratinocytes and macrophages, and plays an critical role in host defense by regulating immune and inflammatory responses. IL-6 stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins and regulates bone metabolism. Murine IL-6 is inactive on human cells, while both human and murine IL-6 are equally active on murine cells.

The rat IL-6 cDNA encodes a 211 aa protein with a 24 aa signal sequence. Recombinant rat IL-6 is a 21.7 kDa protein containing 187 amino acid residues. IL-6 is an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections and is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha.

生物活性

Determined by the dose-dependent stimulation of the proliferation of the IL-6 dependent murine 7TD1 cells.
ED50< 0.01 ng/ml.     
Specific activity> 1*108units/mg.