| 包装 | 价格(元) |
| 10ug | 电议 |
| 50ug | 电议 |
| 1mg | 电议 |
| Gene ID: | UniGene:Rn.9869 | Accession #: | Q63264 |
| Alternate Names: | Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF). | ||
| Source: | Escherichia Coli. | M.Wt: | 17.3 kDa |
| Appearance: | Lyophilized protein | Storage: | Store at -20°C |
| Formulation: | Sterile filtered and then lyophilized from 10 mM Sodium Acetate, pH 6.5. | ||
| Solubility: | Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4℃ for 1 week or -20℃ for future use. | ||
| Shipping Condition: | Gel pack. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. | ||
Interleukin 1 beta (IL-1β) is a proinflammatory cytokine and is produced by activated macrophages, monocytes, keratinocytes and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar biological properties, which includes the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic fibroblast growth factor (FGF)-like activity, and the release of prostaglandin and collagenase from synovial cells. However, IL-1β is a secreted cytokine, whereas IL-1α is predominantly a cell-associated cytokine.
The rat IL-1β cDNA encodes a 268 aa precursor, which is cleaved intracellularly to produce the 153 aa active cytokine. Recombinant rat IL-1β is a 17.3 kDa protein containing 153 amino acid residues.
| Determined by the dose-dependent stimulation of murine D10S cells. | ||||||
| ED50 | < 0.1 ng/ml. | |||||
| Specific activity | > 1*107units/mg. | |||||
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