| 包装 | 价格(元) |
| 10ug | 电议 |
| 50ug | 电议 |
| 1mg | 电议 |
| Gene ID: | 3481 | Accession #: | P01344 |
| Alternate Names: | Human IGF-II, IGF-II, IGFII, IGFII, IGF2, IGF-2, IGF 2, h-IGF-II, rh-IGF-II, recombinant human IGF-II, recombinant IGF-II, IGF. | ||
| Source: | Escherichia Coli. | M.Wt: | 7.5 kDa |
| Appearance: | Lyophilized protein | Storage: | Store at -20°C |
| Formulation: | Lyophilized with no additives. | ||
| Solubility: | Reconstitute in 10 mM acetic acid to a concentration of 0.1-1 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4℃ for 1 week or -20℃ for future use. | ||
| Shipping Condition: | Gel pack. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. | ||
Insulin-like Growth Factor-II (IGF-II) is a polypeptide endocrine hormone structurally similar to insulin and belongs to insulin-like growth factor family. IGF-II have a much higher growth-promoting activity than insulin and binds to the tyrosine kinase type I receptor (IGF-IR) and the IGF-II/Mannose-6-phosphate receptor. IGF-II expression is influenced by placenta lactogen.
Human IGF-II is synthesized as two precursor isoforms with N- and alternate C-terminal propeptides, which are proteolyzed to produce the identical 7.5 kDa mature IGF-II. Mature IGF-II is highly conserved between the human, bovine and porcine proteins (100% identity), and exhibits cross-species activity. Recombinant Human IGF-II is a 7.5 kDa protein containing 67 amino acid residues.
| Determined by competitive binding against plasma-derived IGF-II to human placental membranes. | ||||||
| ED50 | < 1.0 ng/ml. | |||||
| Specific activity | > 1*106units/mg. | |||||
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