| CAS NO: | 96020-91-6 |
| 包装 | 价格(元) |
| 10mM (in 1mL H2O) | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 500mg | 电议 |
| Storage | Store at -20°C |
| M.Wt | 236.6 |
| Cas No. | 96020-91-6 |
| Formula | C6H12F2N2O2·HCl [H2O] |
| Synonyms | DFMO,Eflornithine |
| Solubility | insoluble in DMSO; insoluble in EtOH; ≥11.55 mg/mL in H2O |
| Chemical Name | 2-(difluoromethyl)-ornithine, monohydrochloride, monohydrate |
| Canonical SMILES | FC(F)C(C(O)=O)(N)CCCN.Cl.O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
DL-α-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase.
Ornithine decarboxylase catalyzes the decarboxylation of ornithine to form putrescine, which is the committed step in polyamine synthesis.
DFMO inhibited the polyamine synthesis process and displayed antiangiogenic and cytostatic effects in many human tumor cells. In rat bladder carcinoma cell line-804G cells, DFMO inhibited the growth of 804G cells stimulated by Fraction I or by 10% FCS [2].
In female SENCAR mice with skin tumorigenesis model, both oral intake of DFMO (1.5-2.0% wt/vol) and intraperitoneal injection of DFMO (20mg,i.p. and 5mg,i.p.) reduced the sizes and numbers of skin tumor compared to control group [3].
References:
1. H. M. Wallace, A. V. Fraser and A. Hughes. A perspective of polyamine metabolism. Biochemistry Journal 376(Pt 1), 1-14 (2003).
2. Homma Y, Ozono S, Numata I, Seidenfeld J,et al. Alpha-Difluoromethylornithine inhibits cell growth stimulated by a tumor-promoting rat urinary fraction. Carcinogenesis. 1985 Jan;6(1):159-61.
3. Weeks CE, Herrmann AL, Nelson FR, Slaga TJ. Alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin. Proc Natl Acad Sci U S A. 1982 Oct; 79(19):6028-32.
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