| CAS NO: | 4671-75-4 |
| 包装: | 1g |
| 市场价: | 767元 |
| Storage | Store at -20°C |
| M.Wt | 278.4 |
| Cas No. | 4671-75-4 |
| Formula | C14H31O3P |
| Solubility | ≥27.8 mg/mL in ETOH; insoluble in H2O; ≥2.27 mg/mL in DMSO with gentle warming and ultrasonic |
| Chemical Name | tetradecylphosphonic acid |
| Canonical SMILES | CCCCCCCCCCCCCCP(=O)(O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors. The IC50 value for inhibition of LPA-induced calcium mobilization was 10 μM, 5.5 μM, and 3.1 μM, respectively. At a concentration of 10 μM, tetradecyl phosphonate activates a peroxisome proliferator-activated receptor γ reporter construct 4-fold when compared with the controls and partially inhibits autotaxin with an IC50 value of approximately 3 μM [1].
Lysophosphatidic acid (LPA), also known as autotaxin (ATX), is a lipid signalling molecule formed by the hydrolysis of lysophosphatidyl choline by lysophospholipase D [2]. LPA signals through four different G protein-coupled receptors, named as LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7, and LPA4/GPR23 [3]. It has been reported that LPA was involved in activating peroxisome proliferator-activated receptor γ (PPARγ) [4].
References:
[1]. Durgam G G, Virag T, Walker M D, et al. Synthesis, structure activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARγ, and inhibitors of autotaxin[J]. Journal of medicinal chemistry, 2005, 48(15): 4919-4930.
[2]. Tokumura A, Majima E, Kariya Y, et al. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase[J]. Journal of Biological Chemistry, 2002, 277(42): 39436-39442.
[3]. Noguchi K, Ishii S, Shimizu T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family[J]. Journal of Biological Chemistry, 2003, 278(28): 25600-25606.
[4]. McIntyre T M, Pontsler A V, Silva A R, et al. Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist[J]. Proceedings of the National Academy of Sciences, 2003, 100(1): 131-136.
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