Guanylyl Imidodiphosphate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

148892-91-5

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议

产品介绍

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	588.1
Cas No.	148892-91-5
Formula	C₁₀H₁₄N₆O₁₃P₃·3Na
Solubility	≤10mg/ml in PBS(pH7.2)
Chemical Name	monoanhydride with imidodiphosphoric acid, 5'-guanylic acid, trisodium salt
Canonical SMILES	O[C@H]1[C@H](N2C=NC3=C2N=C(N)NC3=O)O[C@H](COP(OP(NP(O)([O-])=O)([O-])=O)([O-])=O)[C@H]1O.[Na+].[Na+].[Na+]
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Guanylyl Imidodiphosphate is a stimulator of adenylate cyclase.

Adenylyl cyclase, also commonly known as adenyl cyclase and adenylate cyclase, is an enzyme with key regulatory roles in essentially all cells. Adenylyl cyclase is the most polyphyletic known enzyme.

In vitro: A previous study evaluated the properties of microtubules formed in the presence of GTP, 5'-guanylyl imidodiphosphate, and 5'-guanylyl methylenediphosphate to identify features of the assembly or disassembly reactions related to hydrolysis. Results showed that the assembly of microtubules with GTP or 5'-guanylyl imidodiphosphate was similar in rates and extents of assembly, the length distributions, as well as the podophyllotoxin-induced depolymerization. The greater rapidity of 5'-guanylyl methylenediphosphate-supported assembly, however, led to shorter, more numerous microtubules and the rate of podophyllotoxin-induced depolymerization was consistent with an increased number of concentration of microtubules. In addition, it was found that GTP-tubule turnover corresponded to a rate of around 8% of the microtubule protein taken up or released per hour. Moreover, with 5'-guanylyl imidodiphosphate- and 5'-guanylyl methylenediphosphate-tubules, the rates of label uptake by unlabeled microtubules were significantly lower than that observed with guanosine triphosphate [1].

In vivo: Currently, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] B. J. Terry and D. L. Purich. Assembly and disassembly properties of microtubules formed in the presence of GTP, 5'-guanylyl imidodiphosphate, and 5'-guanylyl methylenediphosphate. The Journal of Biological Chemisty 255(21), 10532-10536 (1980).