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4-Quinolone-3-Carboxamide CB2 Ligand
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
4-Quinolone-3-Carboxamide CB2 Ligand图片
CAS NO:1314230-69-7
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt422.6
Cas No.1314230-69-7
FormulaC26H34N2O3
Synonyms4Q3C CB2 Ligand
Solubility≤30mg/ml in ethanol;3mg/ml in DMSO;3mg/ml in dimethyl formamide
Chemical Name1,4-dihydro-8-methoxy-4-oxo-1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-3-quinolinecarboxamide
Canonical SMILESO=C(C1=CN(CCCCC)C2=C(C=CC=C2OC)C1=O)N[C@@]34CC5C[C@H](C4)C[C@H](C3)C5
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Ki: 0.6 nM

4-Quinolone-3-Carboxamide CB2 Ligand is a ligand of the CB2 receptor.

Cannabinoids (CBs) and their synthetic analogs exhibit biochemical and pharmacological effects via interacting with the central CB1 and peripheral CB2 receptors. The CB2 receptor has emerged as a pharmacological target for treating osteoporosis, and for eliciting antinociceptive effects in various pain models .

In vitro: Previous study found that 4-Quinolone-3-carboxamide CB2 Ligand was a selective, high-affinity ligand of the CB2 receptor, displaying an in vitro Ki values of 0.6 nM for CB2 and over 10,000 nM for CB1 [1].

In vivo: In animal study, it was found that 4-quinolone-3-carboxamide CB2 Ligand at a dose of 6 mg/kg showed antinociceptive activity in a formalin test of nocifensive response in mice. Moreover, such analgesic affect could not be significantly reversed by the CB2 antagonist AM630 treatment, which suggested that 4-quinolone-3-carboxamide CB2 Ligand might behave as an inverse agonist [1].

Clinical trial: So far, no clinical study has been conducted for 4-quinolone-3-carboxamide CB2 Ligand.

Reference:
[1] S.  Pasquini, M. De Rosa, V. Pedani, et al. Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice. Journal of Medicinal Chemistry 54, 5444-5453 (2011).