| CAS NO: | 119520-05-7 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 261.3 |
| Cas No. | 119520-05-7 |
| Formula | C14H19N3O2 |
| Synonyms | RU-42173,Zilmax(R) |
| Solubility | ≤1mg/ml in DMSO;0.1mg/ml in dimethyl formamide |
| Chemical Name | (6R,7R)-rel-4,5,6,7-tetrahydro-7-hydroxy-6-[(1-methylethyl)amino]-imidazo[4,5,1-jk][1]benzazepin-2(1H)-one |
| Canonical SMILES | O=C1NC2=CC=CC3=C2N1CC[C@H](NC(C)C)[C@H]3O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Zilpaterol is a β-adrenergic receptor agonist.
β-adrenergic receptors, prototypic G-protein-coupled receptors, play a key role in regulating numerous physiological processes.
In vitro: Previus study found that there was no effect of zilpaterol (ZH) on thymidine incorporation into DNA. ZH at 1 μM could decrease β1-AR mRNA, and 0.01 and 1 μM ZH decreased β2-AR and β3-AR mRNA in myoblasts. There was no effect of ZH on the β-AR or IGF-I gene expression in fused myotube cultures. The β2-AR antagonist ICI-118, 551 attenuated the effect of ZH to reduce expression of β1- and β2-AR mRNA. There was no effect of ICI-118, 551 or ZH on β3-AR or IGF-I. In addition, the total lipid synthesis from acetate was increased by ZH in bovine subcutaneous adipose tissue explants in the absence of theophylline [1].
In vivo: FDA has approved label claims of increased rate of BW gain, improved feed efficiency, and increased carcass leanness. The feeding of ZH for 20 to 40 d with a 3-d withdrawal resulted in significantly increased ADG. Such increases equate to an average of 9 kg heavier BW in ZH-fed steers. Moreover, hot carcass weight has been shown to increase to a larger degree compared with BW, with an average improvement of 15 kg [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Miller, E. K.,Chung, K.Y.,Hutcheson, J.P., et al. Zilpaterol hydrochloride alters abundance of β-adrenergic receptors in bovine muscle cells but has little effect on de novo fatty acid biosynthesis in bovine subcutaneous adipose tissue explants. Journal of Animal Science 90(4), 1317-1327 (2012).
[2] Delmore, R. J.,Hodgen, J.M. and Johnson, B.J. Perspectives on the application of zilpaterol hydrochloride in the United States beef industry. Journal of Animal Science 88(8), 2825-2828 (2010).
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