| CAS NO: | 13515-99-6 |
| 包装 | 价格(元) |
| 5g | 电议 |
| 10g | 电议 |
| 25g | 电议 |
| 50g | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 211.6 |
| Cas No. | 13515-99-6 |
| Formula | C7H13NO4·HCl |
| Synonyms | Glutamic Acid dimethyl ester,Dimethyl 2-aminopentanedioate |
| Solubility | ≤5mg/ml in ethanol;10mg/ml in DMSO;15mg/ml in dimethyl formamide |
| Chemical Name | 1,5-dimethyl ester glutamic acid, monohydrochloride |
| Canonical SMILES | COC(C(N)CCC(OC)=O)=O.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Dimethyl DL-glutamate is a cell-permeable form of glutamate.
Extracellular glutamic acid is an excitatory neurotransmitter, while intracellular glutamic acid is an amino acid that serves various metabolic roles.
In vitro: Dimethyl DL-glutamate at 3.0-10.0 mM could enhance insulin release evoked by 6.0-8.3 mM D-glucose, 1.0-10.0 mM L-leucine, or 5.0-10.0 mM 2-amino-bicyclo(2,2,1)heptane-2-carboxylic acid, resulting in a shift to the left of the sigmoidal relationship between insulin output and D-glucose concentration. Moreover, dimethyl DL-glutamate unmasked the insulinotropic potential of glibenclamide in the absence of D-glucose. In islets exposed to L-leucine, the insulinotropic action of dimethyl DL-glutamate coincided with an early fall and later increase in 86Rb outflow. In addition, the overall gain in O2 uptake represented the balance between dimethyl DL-glutamate oxidation and its sparing action on the catabolism of endogenous fatty acids and exogenous D-glucose [1].
In vivo: Dimethyl DL-glutamate was intravenously administered as a primed constant infusion to adult rats that had been injected with streptozotocin during the neonatal period. Results showed that dimethyl DL-glutamate augmented plasma insulin concentration and potentiated and/or prolonged the insulinotropic action of GLP-1 injected intravenously at min 5 of the test [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Sener, A. ,Conget, I.,Rasschaert, J., et al. Insulinotropic action of glutamic acid dimethyl ester. American Journal of Physiology 267(4 Pt 1), E573-E584 (1994).
[2] Cancelas, J. ,Villaneuva-Peacarrillo, M.L.,Valverde, I., et al. Potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of L-glutamic acid in a type 2 diabetes animal model. Endocrine 16(2), 113-116 (2001).
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