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Conoidin A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Conoidin A图片
CAS NO:18080-67-6
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍

化学性质

StorageStore at -20°C
M.Wt348
Cas No.18080-67-6
FormulaC10H8Br2N2O2
Solubility≥34.8 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
Chemical Name2,3-bis(bromomethyl)-quinoxaline 1,4-dioxide
Canonical SMILES[O-][N+]1=C(CBr)C(CBr)=[N+]([O-])C2=C1C=CC=C2
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Conoidin A is a covalent inhibitor of peroxiredoxin II with IC50 value of 23 μM [2].

Peroxiredoxins are a widely conserved family of enzymes that function in antioxidant defense and signal transduction, and changes in PrxII expression are associated with a variety of human diseases, including cancer [1].

Conoidin A is a novel, cell-permeable and covalent peroxiredoxin II inhibitor with IC50 value of 23 μM [1][2]. Conoidin A bound covalently to the peroxidatic cysteine of the T. gondii enzyme peroxiredoxin II (TgPrxII), inhibiting its enzymatic activity. In human epithelial cells, Conoidin A inhibited hyperoxidation of human PrxII [1]. Conoidin A also inactivated AcePrx-1 (a peroxiredoxin from the hookworm Ancylostoma ceylanicum) by alkylating or crosslinking the catalytic cysteines with IC50 value of 374 μM [2]. Conoidin A inhibited the hyperoxidation of two mammalian peroxiredoxin homologues (PrxI and PrxII) in cells [3].

References:
[1].  Haraldsen JD1, Liu G, Botting CH, et al. IDENTIFICATION OF CONOIDIN A AS A COVALENT INHIBITOR OF PEROXIREDOXIN II. Org Biomol Chem. 2009;7:3040-3048.
[2].  Nguyen JB1, Pool CD, Wong CY, et al. Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A. Chem Biol. 2013 Aug 22;20(8):991-1001.
[3].  Liu G, Botting CH, Evans KM, et al. Optimisation of conoidin A, a peroxiredoxin inhibitor. ChemMedChem. 2010 Jan;5(1):41-5.