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3,3',5'-Triiodo-L-thyronine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3,3',5'-Triiodo-L-thyronine图片
CAS NO:5817-39-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍

化学性质

StorageStore at -20°C
M.Wt651
Cas No.5817-39-0
FormulaC15H12I3NO4
SynonymsReverse T3,rT3,3,3’,5’-T3
Solubility≥32.55 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
Chemical NameO-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-tyrosine
Canonical SMILESIC1=C(O)C(I)=CC(OC2=CC=C(C[C@H](N)C(O)=O)C=C2I)=C1
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

3,3',5'-triiodo-L-thyronine (reverse T3 or rT3) and 3,5,3'-triiodo-L-thyronine (T3) are the metabolism of thyroxine (T4) [1]. 3,3',5'-Triiodo-L-thyronine is thyroid hormone receptors TRα and TRβ antagonist [1].

Thyroid hormones play important roles in the development of the mammalian brain by acting on migration and differentiation of neural cells, synaptogenesis, and myelination. The actions of thyroid hormones are mediated by nuclear thyroid hormone receptors (TRs) and regulation of gene expression. TRs have been also involved in adult brain function. In adult mice, TRα1 deletion and a dominant negative mutant receptor expression induce consistent behavioral changes leading to severe anxiety and morphological changes in the hippocampus [2].

The rT3 was about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ compared with 3,3',5-triiodo-L-thyronine and commonly described as inactive [1].It has been reported that rT3 activates a native form of TRα, TRΔα1, which lacks a nuclear localization signal and functions in the cytoplasm. Through this action, rT3 initiates actin polymerization, particularly in astrocytes and neurons [3].

References:
[1] Nicod P, Burger A, Staeheli V, et al.  A radioimmunoassay for 3, 3′, 5′-triiodo-L-thyronine in unextracted serum: method and clinical results[J]. The Journal of Clinical Endocrinology & Metabolism, 1976, 42(5): 823-829.
[2] Bernal J.  Thyroid hormone receptors in brain development and function[J]. Nature clinical practice Endocrinology & metabolism, 2007, 3(3): 249-259.
[3] Senese R, Cioffi F, De Lange P, et al.  Thyroid: biological actions of ‘nonclassical’thyroid hormones[J]. Journal of Endocrinology, 2014, 221(2): R1-R12.