| CAS NO: | 30675-13-9 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 100mg | 电议 |
| Cas No. | 30675-13-9 |
| 别名 | 4,5,6,7-四氯茚满-1,3-二酮,4,5,6,7-Tetrachloroindan-1,3-dione |
| 化学名 | 4,5,6,7-tetrachloroindene-1,3-dione |
| Canonical SMILES | C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl |
| 分子式 | C9H2Cl4O2 |
| 分子量 | 283.92 |
| 溶解度 | ≥ 16.45mg/mL in DMSO |
| 储存条件 | Store at -20° C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TCID is a potent, selective and cell-permeable inhibitor of UCHL3 (ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)) with IC50 of 0.6 μm. It is also a 125 fold less potent inhibitor of UCH-L1 (IC50 = 75 μm). [1] UCHL3 belongs to the deubiquitinating enzyme family that removes ubiquitin from polypeptides. It processes ubiquitin precursors and ubiquitinated proteins to regulate cellular ubiquitin levels. GlyT2 ubiquitination was diminished by inhibition of UCHL3 with TCID (10 μm) and inhibition of UCHL1 with LDN-57444 (10 μm) in brainstem and spinal cord primary neurons, and the effect was more significant when cell was treated with the inhibitors for a prolonged period. [2] In transfected MDCK cells, TCID (10 μm for 30 mins) was not able to affect the UCH-L1 inhibitor promoted accumulation of YFP-GLT-1 in intracellular vesicles. [3] References: |
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