Trolox

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Trolox

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

53188-07-1

包装与价格：

包装	价格(元)
250mg	电议
500mg	电议
1g	电议

产品介绍

化学性质

Storage	Store at -20°C
M.Wt	250.29
Cas No.	53188-07-1
Formula	C₁₄H₁₈O₄
Solubility	≥25 mg/mL in DMSO; insoluble in H2O; ≥20.75 mg/mL in EtOH
Chemical Name	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
Canonical SMILES	CC(C(C)=C1O2)=C(O)C(C)=C1CCC2(C(O)=O)C
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Trolox is a cell-permeable, derivative of vitamin E with potent antioxidant properties. It is commonly used as a standard or positive control in antioxidant assays[1,2].

Trolox can prevent thymocytes apoptosis which is induced by oxidative stress.Using trolox to pre-treat or post-treat cells can reduce H2O2-induced DNA fragments to below control levels[3].

In a mouse model, after cerebral ischemia-reperfusion, Trolox (50 mg / kg) is prescribed to increase anti-apoptotic proteins and decrease pro-apoptotic proteins, thereby protecting hippocampal neurons and causing improvement in memory[4].

References:

[1]. Cos P, Hermans N, Calomme M, et al. Comparative study of eight well-known polyphenolic antioxidants. Journal of Pharmacy and Pharmacology, 2003, 55(9): 1291-1297.

[2]. Tadolini B, Juliano C, Piu L, et al. Resveratrol inhibition of lipid peroxidation. Free Radical Research, 2000, 33(1): 105-114.

[3]. Forrest V J, Kang Y H, Mcclain D E, et al. Oxidative stress-induced apoptosis prevented by Trolox. Free Radical Biology and Medicine, 1994, 16(6): 675-684.

[4]. Sarveazad A, Babahajian A, Yari A, et al. Neuroprotective Role of Trolox in Hippocampus after Ischemia Reperfusion Injury in Mouse. International Journal for Vitamin and Nutrition Research, 2017, 86(5-6): 228-234.