| CAS NO: | 95734-82-0 |
| 包装 | 价格(元) |
| 10mM (in 1mL Water) | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 95734-82-0 |
| 别名 | 奈达铂,NSC 375101D |
| 化学名 | azanide;2-hydroxyacetic acid;platinum(2+) |
| Canonical SMILES | C(C(=O)O)O.[NH2-].[NH2-].[Pt+2] |
| 分子式 | C2H8N2O3Pt |
| 分子量 | 303.17 |
| 溶解度 | ≥ 9.8mg/mL in Water |
| 储存条件 | Store at -20°C,unstable in solution, ready to use. |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Nedaplatin (NSC 375101D) is a derivative of cisplatin and DNA damage agent. Nedaplatin (NSC 375101D, NDP) is a derivative of cisplatin which produced less nausea & vomiting and nephrotoxicity. the effect of NDP on the 7-ethyl-1-hydroxy-CPT (the active form of CPT-11)-induced inhibitory effect on DNA topoisomerase I was examined. The topoisomerase I-inhibitory effect of 7-ethyl-1-hydroxy-CPT was enhanced 10-fold in the presence of Nedaplatin (NSC 375101D, NDP) at microgram/milliliter concentrations[1]. Nedaplatin (NSC 375101D, NDP) was developed as a second generation platinum complex. Because it has greater antitumour activity and lower nephrotoxicity than cisplatin (CDDP). At the high-dose of Nedaplatin (NSC 375101D, NDP) in FN therapy, a reduction of tumour size and long-term tumour-free survival were frequently observed. The survival effect of the combinations of Nedaplatin (NSC 375101D, NDP) with 5-FU was superior to those of the combination of CDDP with 5-FU. In conclusion, the sequence-dependent antitumour efficacy and toxicity of the combination of NDP or CDDP with 5-FU was demonstrated in this study, and FN therapy appeared to be the most efficient regimen as a clinical therapy[2]. References: |
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