Leelamine 是大麻素受体 CB1 和 CB2 的弱激动剂。 Leelamine 还抑制丙酮酸脱氢酶激酶 (PDK)。 Leelamine 具有抗肿瘤活性。
| Cas No. | 1446-61-3 |
| 别名 | 脱氢松香胺 |
| Canonical SMILES | CC(C)C(C=C1)=CC2=C1[C@]3(C)[C@](CC2)([H])[C@@](CN)(C)CCC3 |
| 分子式 | C20H31N |
| 分子量 | 285.5 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 100 mg/ml,Ethanol:PBS (pH 7.2) (1:3): .25 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Leelamine is a diterpene molecule whose name derives from the Sanskrit word leela which means "play". It has weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM. Leelamine inhibits pyruvate dehydrogenase kinase (PDK) with an IC50 value of 9.5 µM. Derivatives of leelamine exhibit anti-inflammatory activity and show moderate inhibition of phospholipase A2 activity from a variety of sources. |
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