ML298 是一种有效的选择性磷脂酶 D2 (PLD2) 抑制剂，IC50 为 355 nM。 ML298 减少 U87-MG 胶质母细胞瘤细胞的侵袭性迁移。
| Cas No. | 1426916-02-0 |
| Canonical SMILES | FC1=CC=C(C(NCCN2CCC3(C(NCN3C4=CC(F)=CC=C4)=O)CC2)=O)C=C1F |
| 分子式 | C22H23F3N4O2 |
| 分子量 | 432.4 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 20 mg/ml,Ethanol: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ML-298 is an inhibitor of phospholipase D2 (PLD2; IC50 = 355 nM). It is selective for PLD2 over PLD1 (IC50 = 20,000 nM). It decreases invasive migration of U87-MG glioblastoma cells when used at a concentration of 10 µM without inducing cytotoxicity. |
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