| CAS NO: | 11024-24-1 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 1229.31 |
| Cas No. | 11024-24-1 |
| Formula | C56H92O29 |
| Solubility | insoluble in EtOH; ≥122.7 mg/mL in DMSO with ultrasonic; ≥122.9 mg/mL in H2O with ultrasonic |
| Chemical Name | (2S,3R,4S,5S,6R)-2-(((2S,3R,4S,5S,6R)-2-(((2S,3R,4S,5R,6R)-2-(((2R,3R,4R,5R,6R)-6-(((2aS,2'R,4R,5R,5'R,6aS,6bS,8aS,8bR,9S,11aR,12S,12aS,12bR)-5,12-dihydroxy-5',6a,8a,9-tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy) |
| Canonical SMILES | C[C@](CO1)([H])CC[C@@]12[C@@]([C@@]3([H])[C@](O2)([H])[C@](O)([H])[C@@]4([H])[C@]([C@]5([H])CC[C@]34C)([H])CC[C@@]6([H])C[C@](O[C@@]7([H])[C@@](O)([H])[C@](O)([H])[C@](O[C@@]8([H])[C@@](O[C@@]9([H])[C@@](O)([H])[C@](O[C@@]%10([H])[C@@](O)([H])[C@](O)([H]) |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Digitonin is a detergent that binds to cholesterol molecules in the cell membrane to increase cell permeability [1]. Digitonin has increased the uptake of a cisplatin analog into human ovarian carcinoma cells in vitro by a factor of 4 [2].
In LH rats, intraperitoneal administration of carboplatin at 5 mg / kg can inhibit tumor growth, and digitalis saponins can enhance this inhibition. Digitonin is administered with carboplatin at a dose of 5 mg/kg and no increase in toxicity is observed. Systemic administration of carboplatin is not influenced by digitonin. Pretreatment with digitonin increases the tumour uptake of carboplatin and potentiates the cytotoxic effect of carboplatin.
References：
[1]. Vercesi A E, Bernardes C F, Hoffmann M E, et al. Digitonin permeabilization does not affect mitochondrial function and allows the determination of the mitochondrial membrane potential of Trypanosoma cruzi in situ. Journal of Biological Chemistry, 1991, 266(22): 14431-4.
[2]. Jekunen A P, Shalinsky D R, Hom D K, et al. Modulation of cisplatin cytotoxicity by permeabilization of the plasma membrane by digitonin in vitro. Biochemical Pharmacology, 1993, 45(10): 2079-2085.
[3]. Lindnér P G, et al. Digitonin enhances the efficacy of carboplatin in liver tumour after intra-arterial administration. Cancer Chemother Pharmacol, 1997, 40(5): 444-8.
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