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Necrostatin-7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Necrostatin-7图片
CAS NO:351062-08-3
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
Necrotatin-7 (Nec-7) 是一种有效的坏死性凋亡抑制剂,EC50 为 10.6 μM。 Necrotatin-7 不抑制重组 RIP1 激酶。
Cas No.351062-08-3
别名5-[[3-(4-氟苯基)-1H-吡唑-4-基]亚甲基]-2-亚氨基-3-(2-噻唑基)-4-噻唑烷酮,Nec-7
Canonical SMILESO=C(N(C1=NC=CS1)C(S/2)=N)C2=C\C3=CN([H])N=C3C4=CC=C(F)C=C4
分子式C16H10FN5OS2
分子量371.4
溶解度DMSO: Soluble,Ethanol: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-7 (Nec-7) is a necroptosis inhibitor that is structurally and biologically distinct from necrostatin-1, -3, -4, and -5 as it does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in this pathway as it inhibits TNF-α-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 μM.