| 包装: | 1mg |
| 市场价: | 1028元 |
| Canonical SMILES | NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC(CN[H])=O)=O)=O)CC1=CNC2=C1C=CC=C2)=O)C)=O)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)CCSC)=O.OC(C(F)(F)F)=O |
| 分子式 | C52H73N15O12S•XCF3COOH |
| 分子量 | 1132.3 |
| 溶解度 | Water: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Neuromedin B (NMB) is a peptide agonist of the NMB receptor (Ki = 7.4 nM in NCI-H1299 small cell lung cancer cells expressing the human receptor). It displays similar affinity for frog [Phe13]bombesin receptors (Ki = 11 nM) and lower affinities for human gastrin-releasing peptide receptor and bombesin receptor subtype 3 (Kis = 440 and 4,800 nM, respectively). Intrathecal administration of NMB (0.1-1 nmol) induces dose-dependent itching behavior in mice. NMB (50 μg, s.c.) reduces serum thyroid stimulating hormone (TSH) by 30% in mice indicating a role in pituitary-thyroid axis function. In rodents, NMB is also involved in mediating stress and fear responses, thermoregulation, and can stimulate the contraction of the uterus and gastrointestinal smooth muscle. |
m.cnreagent.com