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Pioglitazone(potassium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pioglitazone(potassium salt)图片
CAS NO:1266523-09-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
吡格列酮 (U 72107) 钾是一种具有口服活性和选择性的 PPARγ; (过氧化物酶体增殖物激活受体)激动剂,与 PPARγ 具有高亲和力;配体结合结构域,EC50 分别为 0.93 μM 和 0.99 μM 对于人和小鼠 PPARγ,分别。
Cas No.1266523-09-4
别名U 72107 potassium
Canonical SMILESCCC1=CC=C(CCOC2=CC=C(CC(C3=O)SC([N-]3)=O)C=C2)N=C1.[K+]
分子式C19H19N2O3S•K
分子量394.5
溶解度DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ). It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM. Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM. In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats. It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model. Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW9662 .