PTP1B Inhibitor 是蛋白质酪氨酸磷酸酶 PTP1B 的非竞争性变构抑制剂，IC50 为 8 μM。
| Cas No. | 765317-72-4 |
| 别名 | 3-(3,5-二溴-4-羟基苯甲酰基)-2-乙基-N-[4-[(2-噻唑氨基)磺酰基]苯基]-6-苯并呋喃磺酰胺 |
| Canonical SMILES | O=S(NC1=CC=C(S(NC2=NC=CS2)(=O)=O)C=C1)(C3=CC=C(C(C(C4=CC(Br)=C(O)C(Br)=C4)=O)=C(CC)O5)C5=C3)=O |
| 分子式 | C26H19Br2N3O7S3 |
| 分子量 | 741.5 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 10 mg/ml |
| 储存条件 | Store at -20℃, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer. PTP1B inhibitor is a cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 µM for 403 and 298 residue PTP1B forms, respectively). It binds reversibly and non-competitively, altering the conformation of the catalytic pocket. PTP1B inhibitor selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the action of insulin. |
m.cnreagent.com