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Reduced Haloperidol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Reduced Haloperidol图片
CAS NO:34104-67-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Reduced haloperidol is an active metabolite of haloperidol.
Cas No.34104-67-1
别名还原氟哌啶醇
Canonical SMILESOC1(CCN(CCCC(C2=CC=C(F)C=C2)O)CC1)C3=CC=C(Cl)C=C3
分子式C21H25ClFNO2
分子量377.9
溶解度Dichloromethane: slightly soluble,Methanol: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing the human transporters). Reduced haloperidol (0.5 mg/kg) increases latency to paw withdrawal in mouse models of capsaicin- but not force-induced mechanical hypersensitivity.