NADP+(sodium salt hydrate)

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CAS NO:

698999-85-8

包装与价格：

包装	价格(元)
50mg	电议
100mg	电议
250mg	电议

产品介绍

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	783.4
Cas No.	698999-85-8
Formula	C₂₁H₂₉N₇NaO₁₈P₃
Solubility	insoluble in EtOH; insoluble in DMSO; ≥110.8 mg/mL in H2O
Canonical SMILES	O[C@H]1[C@H]([C@@H](O[C@@H]1COP(OP(OC[C@@H]2[C@H]([C@H]([C@@H](O2)[N+]3=CC(C(N)=O)=CC=C3)O)O)([O-])=O)([O-])=O)N4C=NC5=C4N=CN=C5N)OP(O)(O)=O.[Na+].O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

NADP⁺ (sodium salt hydrate) is the oxidized form of the electron donor, reduced nicotinamide adenine dinucleotide phosphate (NADPH) [1].

NADP⁺ and NADPH are two fundamental common mediators involved in many biological processes, such as energy metabolism, mitochondrial functions, calcium homeostasis, antioxidation/generation of oxidative stress, gene expression, immunological functions, aging, and cell death. NADP⁺ and NADPH are mainly used by the enzymes that catalyze substrate reduction [1].

In cell extracts of human heteroploid cell lines HeLa and T-9, addition of NADP⁺ at 10^-3 M stabilized glucose-6-phosphate dehydrogenase [2]. In air-dried and intact cells ofGluconobacter suboxydans, increasing concentrations of NADP⁺, up to 10 μmol/ml, led to increased NADPH production. However, NADP⁺ at concentrations more than 50 μmol/ml did not increase or markedly decrease the production of NADPH, which was considered to be due to acidification of the reaction mixture on the addition of a high concentration of free NADP⁺ and also on the formation of a large amount of gluconic acid via gluconolactone [3].

References:

[1]. Ying W. NAD⁺/NADH and NADP⁺/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxidants & Redox Signaling, 2008, 10(2): 179-206.

[2]. Alekseev S B, Mamaev V B, Zgurskii A A, et al. Stability of glucose-6-phosphate dehydrogenase in human cells cultivated in vitro. Biokhimiia, 1979, 44(6): 1093-1100.

[3]. Izumi Y , Nath P K , Yamamoto H , et al. NADPH production from NADP⁺ with a glucose dehydrogenase system involving whole cells and immobilized cells ofGluconobacter suboxydans. Applied Microbiology and Biotechnology, 1989, 30(4): 337-342.