化学性质
| Storage | Store at -20°C |
| M.Wt | 503.38 |
| Cas No. | 1707289-21-1 |
| Formula | C24H24Cl2N4O4 |
| Synonyms | Fisogatinib |
| Solubility | ≥50.4 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide |
| Canonical SMILES | COC1=CC(OC)=C(Cl)C(C2=CC3=CN=C(N[C@H]4[C@@H](NC(C=C)=O)CCOC4)N=C3C=C2)=C1Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
资料参考
BLU-554 is an effective, highly selective, orally active FGFR4 inhibitor with IC50 of 5 nM. The IC50 range for FGFR1-3 is 624-2203 nM. In vitro, BLU-554 interacts with FGFR4 and has high potency and selectivity for FGFR4 inhibition; in vivo, BLU-554 is well tolerated in tumor models and induces tumor regression in liver cancer models.
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