Imipenem

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Imipenem

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

64221-86-9

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	299.35
Cas No.	64221-86-9
Formula	C₁₂H₁₇N₃O₄S
Solubility	insoluble in EtOH; insoluble in DMSO; ≥29.9 mg/mL in H2O with gentle warming
Chemical Name	(5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Canonical SMILES	C[C@](O)([H])[C@](C1=O)([H])[C@@](N21)([H])CC(SCCNC=N)=C2C(O)=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Imipenem is one of the semisynthetic thienamycins with antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, which is stable to many beta-lactamases and shows a long half-life because of binding to plasma proteins [1].

Penicillin-binding proteins (PBPs) are a kind of membrane proteins, widely existing on the surface of bacteria, which is the main target site of beta-lactam antibiotics.

In E.coli and selected strains of P.aeruginosa, imipenem has shown to have the highest affinity to PBP-2, PBP-1a, and PBP-1b [2]. The inhibition of PBPs reduces the number of peptidoglycan polymer in the bacterial cell, thus prevent the forming of the bacterial cell wall and lead to cell death [3].

Reference:

[1] Zhanel G G, Wiebe R, Dilay L, et al. Comparative review of the carbapenems [J]. Drugs, 2007, 67(7): 1027-52.

[2] Nicolau D P. Carbapenems: a potent class of antibiotics [J]. Expert Opin Pharmacother. 2008, 9(1): 23-37.

[3] Brunton L L, Hilal-Dandan R, Knollmann B C. eds (2018). Goodman & Gilman's: The Pharmacological Basis of Therapeutics (13th ed.). McGraw-Hill Education.

试验操作

Cell experiment:[1]
Cell lines	Polymorphonuclear leucocytes (PMNs) and lymphomonocytes
Reaction Conditions	15, 30 and 60 mg/l imipenem
Applications	Preincubation of PMNs with the highest dosages (30 and 60 mg/l) was found to increase phagocytosis, while no effect was detected on superoxide anion production, as well as on lymphomonocyte proliferative response and cytokine production.
Animal experiment:[2]
Animal models	Male Sprague-Dawley rats aged 8 ~ 10 weeks and weighing 150 ~ 250 g, subjected to cecal ligation and puncture (CLP)
Dosage form	120 mg/kg Injected intraperitoneally 6 h post-CLP and every 12 h for a total of 7 days
Applications	Imipenem combined with low-dose cyclophosphamide (CTX) could improve the survival rate of rats with sepsis compared with rats treated with imipenem alone. However, this combination significantly reduced IL-10 expression, potentially causing damage to the intestinal barrier function.
Note	The technical data provided above is for reference only.
	References: 1. Pasqui AL, Di Renzo M, Bruni F, et al. Imipenem and immune response: in vitro and in vivo studies. Drugs under Experimental and Clinical Research, 1995, 21(1): 17-22. 2. Guo P, Zhang SW, Zhang J, et al. Effects of imipenem combined with low-dose cyclophosphamide on the intestinal barrier in septic rats. Experimental and Therapeutic Medicine, 2018, 16(3): 1919-1927.