| CAS NO: | 26575-95-1 |
| 包装: | 20mg |
| 市场价: | 1920元 |
| Storage | Store at -20°C |
| M.Wt | 514.74 |
| Cas No. | 26575-95-1 |
| Formula | C32H50O5 |
| Synonyms | Alisol B 23-monoacetate; Alisol B monoacetate |
| Solubility | ≥51.5 mg/mL in DMSO; insoluble in H2O; ≥54.1 mg/mL in EtOH |
| Chemical Name | [1-(3,3-dimethyloxiran-2-yl)-3-[(8S,10S,11S,14R)-11-hydroxy-4,4,8,10,14-pentamethyl-3-oxo-1,2,5,6,7,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-17-yl]butyl] acetate |
| Canonical SMILES | O=C(C)O[C@@H]([C@H]1OC1(C)C)C[C@H](C)C2=C(C[C@H](O)[C@@H]3[C@]4(C)CC[C@H]5[C@]3(C)CCC(C5(C)C)=O)[C@]4(C)CC2 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Alisol B 23-acetate is an agonist of farnesoid X receptor (FXR) [1].
FXR is a member of the nuclear receptor superfamily of ligand-activated transcription factors, playing a critical role in liver regeneration. Alisol B 23-acetate activates FXR-mediated regulation of genes involved in hepatocyte proliferation, potentially becoming a novel therapeutic option for facilitating efficient liver regeneration in patients subjected to liver resection [1].
In HepG2 cells transiently cotransfected with FXR expression plasmid, and FXR target gene, bile salt export pump (BSEP) promoter reporter vector, Alisol B 23-acetate at doses of 0.1, 1 and 10 μM significantly increased luciferase activity. Additional increases were detected in cells treated with higher doses and reached a highest increase (4.3-fold) in cells treated with 10 μM of Alisol B 23-acetate [1].
In male C57BL6 mice received partial hepatectomy, Alisol B 23-acetate treatment (12.5, 25 or 50 mg/kg/d, p.o., for 7 days) significantly increased the ratio of liver regrowth, in a dose-dependent manner. In addition, significant increases in hepatocyte DNA synthesis and mitotic index could also be observed in Alisol B 23-acetate-treated mice, indicating that Alisol B 23-acetate promoted liver regeneration via enhancing hepatocyte proliferation [1].
Reference:
[1]. Meng Q, Chen X, Wang C, et al. Alisol B 23-acetate promotes liver regeneration in mice after partial hepatectomy via activating farnesoid X receptor. Biochemical Pharmacology, 2014, 92(2): 289-298.
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