生物活性
1-Hexadecanol is often used to make other chemicals used in detergents, cleaners, to help make plastics, adhesives and to help change the thickness of liquid products. 1-Hexadecanol is also used directly in cosmetics and personal care products.1-Hexadecanolis used as a skin softener and to help skin keep its moisture. It helps keep oils and water mixed together and change the thickness of liquid products. 1-Hexadecanol is used to turn creams an opaque color which protects the product from light. It can also be used as a lubricant for nuts, bolts, washers, pins and other fasteners. 1-Hexadecanol has a low toxicity when it is breathed in, swallowed, or touches the skin. The main hazard of 1-Hexdecanol is it can cause mild to moderate skin and eye irritation. The irritation is short lasting and will go away after you are no longer exposed. 1-Hexadecanol does not cause damage to genes. 1-Hexadecanol is easily broken down by the body. This prevents 1-Hexadecanol from building up in the body.
化学数据
分子量 | 242.44 |
分子式 | C16H34O |
CAS号 | 36653-82-4 |
纯度 | >98% |
溶解性(25°C) | DMSO 50 mg/mL |
储存和运输条件 | 固体粉末: -20°C 冷藏长期储存 常温运输及临时存放 |
不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)
| 小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 |
重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km系数 | 3 | 6 | 12 | 8 | 5 | 20 |
动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
动物 A的Km系数 |
例如,依据体表面积折算法,将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量,需要将20 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到化合物用于大鼠的等效剂量为10 mg/kg。
储备液配制
以下数据基于产品分子量,对于特殊产品,请参照COA中的储备液配制条件和说明进行操作。
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 4.1247 mL | 20.6237 mL | 41.2473 mL |
5 mM | 0.8249 mL | 4.1247 mL | 8.2495 mL |
10 mM | 0.4125 mL | 2.0624 mL | 4.1247 mL |