化学性质
| Physical Appearance | A yellow oil |
| Storage | Store at -20°C |
| M.Wt | 456.98 |
| Cas No. | 176708-42-2 |
| Formula | C24H25ClN2O3S |
| Synonyms | KN 92;KN92 |
| Solubility | insoluble in H2O; ≥15.1 mg/mL in DMSO; ≥24.2 mg/mL in EtOH with gentle warming |
| Chemical Name | (E)-N-(2-(((3-(4-chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-4-methoxybenzenesulfonamide |
| Canonical SMILES | CN(CC1=CC=CC=C1NS(=O)(C2=CC=C(OC)C=C2)=O)C/C=C/C3=CC=C(Cl)C=C3 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
资料参考
KN-92 is an inactive derivative of KN-93. It is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell.
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