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Cyanidin Chloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cyanidin Chloride图片
CAS NO:528-58-5
包装:20mg
市场价:2310元

产品介绍
Cyanidin Chloride (IdB 1027) 是花青素的一个子类,具有抗氧化和抗癌特性。 Cyanidin Chloride (IdB 1027) 抑制破骨细胞形成、羟基磷灰石再吸收和 NF-κB 配体 (RANKL) 诱导的破骨细胞标记基因表达的受体激活剂。
Cas No.528-58-5
别名氯化花青素; IdB 1027
化学名2-(3,4-dihydroxyphenyl)chromenylium-3,5,7-triol;chloride
Canonical SMILESC1=CC(=C(C=C1C2=C(C=C3C(=CC(=CC3=[O+]2)O)O)O)O)O.[Cl-]
分子式C15H11O6Cl
分子量322.7
溶解度≥ 33.3 mg/mL in DMSO, ≥ 13.04 mg/mL in EtOH, ≥ 10.83 mg/mL in Water with gentle warming
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cyanidin Chloride (IdB 1027), a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties. Cyanidin Chloride (IdB 1027) inhibits osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene expression[1].

Cyanidin Chloride (IdB 1027) inhibits receptor activator of NF-κB ligand (RANKL)-induced NF-κB activation, suppresses the degradation of IκB-α and attenuates the phosphorylation of extracellular signal-regulated kinases (ERK). Cyanidin Chloride (IdB 1027) abrogates RANKL-induced calcium oscillations, the activation of nuclear factor of activated T cells calcineurin-dependent 1 (NFATc1), and the expression of c-Fos[1].

Cyanidin Chloride (IdB 1027) protects against OVX-induced bone loss in OVX-induced osteoporosis mouse model[1].

References:
[1]. Cheng J, et al. Cyanidin Chloride inhibits ovariectomy-induced osteoporosis by suppressing RANKL-mediated osteoclastogenesis and associated signaling pathways. J Cell Physiol. 2018 Mar;233(3):2502-2512.