| CAS NO: | 136572-09-3 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 100mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 677.18 |
| Cas No. | 136572-09-3 |
| Formula | C33H45ClN4O9 |
| Solubility | ≥23.1 mg/mL in DMSO; insoluble in EtOH; ≥2.5 mg/mL in H2O with gentle warming and ultrasonic |
| Chemical Name | (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate |
| Canonical SMILES | O=C(N1CCC(CC1)N2CCCCC2)OC3=CC4=C(CC)C5=C(C(N6C5)=CC(C7(CC)O)=C(COC7=O)C6=O)N=C4C=C3.Cl.O.O.O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Irinotecan HCl Trihydrate(CPT-11)是一种喜树碱的半合成衍生物,在P388白血病细胞中的IC50值为3.4 μM[1].
CPT-11是为了避免喜树碱的毒性并提高其疗效而合成出来的.已经被FDA批准用于治疗患有结肠或直肠转移癌的患者,其疾病在基于5-氟尿嘧啶的治疗中出现复发或进展.CPT-11是一种可溶的SN-38的前药,它在体内通过羧酸酯酶转化成SN-38.SN-38是一种有效的拓扑异构酶I抑制剂[2].
CPT-11被发现对耐药和药物敏感的肿瘤细胞有效.CPT-11抑制VCR或ADM耐药性肿瘤的生长.在VCR或ADM耐药性肿瘤的荷瘤小鼠中,也会发生这种抑制作用[1].
参考文献：
[1] Tsuruo T, Matsuzaki T, Matsushita M, Saito H, Yokokura T. Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo. Cancer Chemother Pharmacol. 1988;21(1):71-4.
[2] Slatter JG, Schaaf LJ, Sams JP, Feenstra KL, Johnson MG, Bombardt PA, Cathcart KS, Verburg MT, Pearson LK, Compton LD, Miller LL, Baker DS, Pesheck CV, Lord RS 3rd. Pharmacokinetics, metabolism, and excretion of irinotecan (CPT-11) following I.V. infusion of [(14)C]CPT-11 in cancer patients. Drug Metab Dispos. 2000 Apr;28(4):423-33.
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