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Losartan
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Losartan图片
CAS NO:114798-26-4
包装与价格：
包装价格(元)
1g电议
5g电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at -20°C
M.Wt422.91
Cas No.114798-26-4
FormulaC22H23ClN6O
Solubility≥2.48 mg/mL in H2O with gentle warming and ultrasonic; ≥2.9 mg/mL in EtOH with gentle warming; ≥84.6 mg/mL in DMSO
Chemical Name[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Canonical SMILESCCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Losartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

试验操作

Cell experiment:[1]

Cell lines

Vascular smooth muscle cells (VSMCs)

Reaction Conditions

0, 1, 5, 10 μM losartan for 48 h incubation

Applications

Losartan dose-dependently decreased the angiotensin Ⅱ (Ang Ⅱ)- or 15% fetal bovine serum (FBS)-induced VSMC proliferation by inhibiting the expression of cell cycle associated proteins, such as p-Rb, cyclin D, and cyclin E.

Animal experiment:[2]

Animal models

Wistar-Kyoto (WKY) rats and stroke-prone, spontaneously hypertensive rats (SHR-SP)

Dosage form

10 mg/kg/day

Administered by oral route for 2 weeks

Applications

In SHR-SP, losartan decreased systolic blood pressure, increased the number of circulating endothelial progenitor cells (EPCs) and colony formation, and inhibited oxidation. In addition, losartan was able to stimulated EPC migration. These data suggest that losartan can improve the proliferation and function of EPCs in hypertension, with the potential to repair hypertensive vascular injuries.

Note

The technical data provided above is for reference only.

References:

1. Kim JE, Choi HC. Losartan inhibits vascular smooth muscle cell proliferation through activation of AMP-activated protein kinase. The Korean Journal of Physiology & Pharmacology, 2010, 14(5): 299-304.

2. Yao EH, Fukuda N, Matsumoto T, et al. Losartan improves the impaired function of endothelial progenitor cells in hypertension via an antioxidant effect. Hypertension Research, 2007, 30(11): 1119-1128.