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Carisbamate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Carisbamate图片
CAS NO:194085-75-1
包装与价格:
包装价格(元)
500μg电议
1mg电议

产品介绍
Carisbamate (RWJ-333369) 是一种口服活性神经调节剂。
Cas No.194085-75-1
别名RWJ-333369
化学名(1S)-1-(2-chlorophenyl)-1,2-ethanediol, 2-carbamate
Canonical SMILESClC1=C([C@H](O)COC(N)=O)C=CC=C1
分子式C9H10ClNO3
分子量215.6
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 Carisbamate is an antiepileptic agent., In vivo, administration of carisbamate (10-60 mg/kg) dose-dependently reduces spike and wave discharges in the frontoparietal cortex in a rat model of absence seizures. Carisbamate (10 mg/kg) increases latency to the first running episode in the Wistar audiogenic sensitive rat model of convulsive seizures. It also reduces motor seizure frequency in a rat model of spontaneous seizures in a dose-dependent manner. Carisbamate blocks Nav1.2 channels (IC50 = 68 μM for rat channels) and inhibits repetitive firing of action potentials in rat hippocampal neurons in a dose-dependent manner. It also reduces T-type Ca2+ currents in HEK cells transfected with human recombinant Cav3.1 channels at a concentration of 300 μM.